Welcome once again to the journal club. Justin is back with TEN papers to discuss. There are a few practice changers in here and some serious acronyms to digest. Of course there is also a paper about eating marshmallows and deciding when trephination in the ED is appropriate!
As ever, we really want you to think these through for yourself. Don’t believe anything we say as we are just two dudes on the internet. The full PDFs are linked below so you can download and dissect at your leisure.
The PSP trial: Brown SGA, Ball EL, Perrin K, et al. Conservative versus Interventional Treatment for Spontaneous Pneumothorax. The New England journal of medicine. 2020; 382(5):405-415. PMID: 31995686
Karadaş A, Doğan NÖ, Pinar SG, et al. A randomized controlled trial of the effects of local tranexamic acid on mortality, rebleeding, and recurrent endoscopy need in patients with upper gastrointestinal hemorrhage. European journal of gastroenterology & hepatology. 2020; 32(1):26-31. PMID: 31567714
Butler CC, van der Velden AW, Bongard E, et al. Oseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial. Lancet. 2020; 395(10217):42-52. PMID: 31839279
McCormack JP, Holmes DT. Your results may vary: the imprecision of medical measurements. BMJ (Clinical research ed.). 2020; 368:m149. PMID: pubmed
Howard A, Krishnan V, Lane G, Caird J. Cranial burr holes in the emergency department: to drill or not to drill? Emergency medicine journal : EMJ. 2019; PMID: 31888954
Mendonça CN, Silva PM, Avelleira JC, Nishimori FS, Cassia Fde F. Shiitake dermatitis. Anais brasileiros de dermatologia. ; 90(2):276-8. PMID: 25831007
The EXTEND Trial: Ma H, Campbell BCV, Parsons MW, et al. Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke. The New England journal of medicine. 2019; 380(19):1795-1803. PMID: 31067369
The WAKE UP Trial: Thomalla G, Simonsen CZ, Boutitie F, et al. MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset. The New England journal of medicine. 2018; 379(7):611-622. PMID: 29766770
Clarebrough E, Guest G, Stupart D. Eating marshmallows reduces ileostomy output: a randomized crossover trial. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 2015; 17(12):1100-3. PMID: 25951410