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PODCAST: Vancomycin by Continuous Infusion

A few weeks ago I posted on Vancomycin and the Nephrocidal Maniacs – in that post I described the problems that we have in the Kimberley with MRSA, renal disease and sepsis.  We walk a fine line between toxicity and efficacy when we treat our patients with severe, limb-threatening infections. I have learned a lot […]

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I: Vancomycin & the Nephrocidal Maniacs

Vancomycin was first isolated in 1953 by Edmund Kornfeld from a soil sample collected from the jungles of Borneo by a missionary. It is produced by the soil bacterium Amycolatopsis orientalis. It was first licensed for use in patients with penicillin resistant Staph infections in 1958. Yes, vancomycin has been around longer than the Beatles! […]

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VTE Risk and Prophylaxis: Devil in the Details

VTE is a problem – there is definitely a risk of hospitalized patients acquiring and either dying or developing complications from VTE. The problem is that “hospitalized patients” includes very heterogeneous groups of patients.  We know that the higher risk groups DO benefit from appropriate VTE prophylaxis: Orthopaedic surgical patients General and gynaecological surgery Oncological […]

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Old Doc, New Drug: Gliflozins

Quick confession: I have never read or seen anything about Harry Potter in my life.  It isn’t because I am opposed to the Rowling machine.  I just grew up at the time before Harry and then had kids who missed the last few episodes…  I guess I have a lot to look forward to, one day […]

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Paracetamol PR for Febrile Seizures?

Today I am reviewing a paper from the Paediatric literature that has created a small stir.  Ever since I trained we have managed simple, febrile seizures with no active intervention other than symptom relief and watchfulness.  The Paediatric party-line, based on some data, is that using anti-pyretic medications will not change the prognosis or rate of […]