First10EM Journal Club: July 2024
Welcome to another episode of the Journal Club with Justin. This onth we look at a big trail that may change our airway approach in the ED… and then a pile of things that probably should not be in our practice at this point! So grab a cup, enjoy the nerdy debate and learn with us on the journal club!
As usual – the free PDFs are available by clicking on the titles below – so please read and make up your own minds.
PreOXI: could be a game changer
Gibbs KW, Semler MW, Driver BE, Seitz KP, et al. Noninvasive Ventilation for Preoxygenation during Emergency Intubation. N Engl J Med. 2024 Jun 13. doi: 10.1056/NEJMoa2313680. PMID: 38869091
Read Justin’s full review of the trial here
Andexanet is expensive and harmful – a drug company sponsored RCT proving it is rubbish!
Connolly SJ, Sharma M, Cohen AT, et al. Andexanet for Factor Xa Inhibitor-Associated Acute Intracerebral Hemorrhage. N Engl J Med. 2024 May 16;390(19):1745-1755. doi: 10.1056/NEJMoa2313040. PMID: 38749032
Justin’s Full write up here.
Aslanger: Another OMI pattern to learn
Aslanger E, Yıldırımtürk Ö, Şimşek B, Sungur A, Türer Cabbar A, Bozbeyoğlu E, Karabay CY, Smith SW, Değertekin M. A new electrocardiographic pattern indicating inferior myocardial infarction. J Electrocardiol. 2020 Jul-Aug;61:41-46. doi: 10.1016/j.jelectrocard.2020.04.008. Epub 2020 Apr 13. PMID: 32526537
NPA to rescue your NGT failures?
Huang TY, Lin JR, Chung YT. A preinstalled nasopharyngeal airway in the right nasal passageway to facilitate nasogastric intubation in anesthetized and intubated patients: a prospective randomized controlled trial. BMC Gastroenterol. 2020 Nov 3;20(1):365. doi: 10.1186/s12876-020-01514-6. PMID: 33143639NCT03697642
Is Methylene Blue a magic bullet in sepsis… not sure at this point
Pruna A, Bonaccorso A, Belletti A, Turi S, Di Prima AL, D’amico F, Zangrillo A, Kotani Y, Landoni G. Methylene Blue Reduces Mortality in Critically Ill and Perioperative Patients: A Meta-Analysis of Randomized Trials. J Cardiothorac Vasc Anesth. 2024 Jan;38(1):268-274. doi: 10.1053/j.jvca.2023.09.037. Epub 2023 Oct 1. PMID: 37880041
You can read my full discussion of this evidence here: Methylene Blues
Paxlovid does not work for short or long Covid
STOP-PASC: Geng LN, Bonilla H, Hedlin H, et al. Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection: The STOP-PASC Randomized Clinical Trial. JAMA Intern Med. 2024 Jun 7:e242007. doi: 10.1
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About The Author
Casey Parker
I am a GP working in Broome, NW of Western Australia. I work as a hospital DMO (District Med Officer) doing Emergency, Anaesthestics, some Obstetrics and a lot of miscellaneous primary care. Also on the web as @broomedocs | + Casey Parker | Contact