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First10EM Journal Club: August 2019

Hello! We are back.  After nearly 2 months of hiking, cruising, paddling and driving all over North America I have just returned to sunny Broome and managed to do some actual work.  Apologies for the downtime and I hope you enjoyed the collaboration projects. Justin Morgenstern has sent me another batch of papers which we […]

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PODCAST: Vancomycin by Continuous Infusion

A few weeks ago I posted on Vancomycin and the Nephrocidal Maniacs – in that post I described the problems that we have in the Kimberley with MRSA, renal disease and sepsis.  We walk a fine line between toxicity and efficacy when we treat our patients with severe, limb-threatening infections. I have learned a lot […]

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I: Vancomycin & the Nephrocidal Maniacs

Vancomycin was first isolated in 1953 by Edmund Kornfeld from a soil sample collected from the jungles of Borneo by a missionary. It is produced by the soil bacterium Amycolatopsis orientalis. It was first licensed for use in patients with penicillin resistant Staph infections in 1958. Yes, vancomycin has been around longer than the Beatles! […]

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Old Doc, New Drug: Ticagrelor

We all love to interfere with the clotting cascade in modern medicine, and this is a new way to do so!  Yet another unpronounceable new drug.  Ti-CAG-re-lor  is the latest in the family of drugs [cyclopentyltriazolopyrimidines.. forget that word immediately ] that stop clots and start bleeding.  I like to call it “tiger claw” and everyone around […]

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Old Doc, New Drug: Umeclidinium

When I first saw the name of this medication… I honestly thought that some smart physicist had discovered a new element way down the bottom of the period table.  Naturally, being a total chemistry nerd, I was excited… until I realised that it was in fact just another boring drug to treat the most mundane […]